Nashae4687 Nashae4687 24-01-2018 Health contestada Which is not caused by the combined effects of nicotine, tar, and carbon monoxide on the cardiovascular system? A smoker is two to three times more likely to have a heart attack. Smokers are 10 times more likely to develop circulation problems. Cigarette smoking doubles a person’s chances of suffering a stroke. A smoker’s neurotransmitters are replaced with new chemicals.